Synthesis of Benzo[b]furans by Intramolecular C–O Bond Formation Using Iron and Copper Catalysis | Zendy

Martyn C. Henry | Zendy; Andrew Sutherland | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Synthesis of Benzo[b]furans by Intramolecular C–O Bond Formation Using Iron and Copper Catalysis

Author(s) -

Martyn C. Henry,

Andrew Sutherland

Publication year - 2020

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.0c00754

Subject(s) - chemistry , intramolecular force , regioselectivity , catalysis , furan , ring (chemistry) , halogenation , aryl , copper , medicinal chemistry , transition metal , stereochemistry , combinatorial chemistry , organic chemistry , alkyl

One-pot processes for the synthesis of benzo[ b ]furans from 1-aryl- or 1-alkylketones using nonprecious transition metal catalysts have been developed. Regioselective iron(III)-catalyzed halogenation of the aryl ring, followed by iron- or copper-catalyzed O -arylation allowed the synthesis of various structural analogues, including the benzo[ b ]furan-derived natural products corsifuran C, moracin F, and caleprunin B.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research