Photoredox/Nickel Dual-Catalyzed Reductive Cross Coupling of Aryl Halides Using an Organic Reducing Agent | Zendy

Abhishek Dewanji | Zendy; Raoul F. Bülow | Zendy; Magnus Rueping | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Photoredox/Nickel Dual-Catalyzed Reductive Cross Coupling of Aryl Halides Using an Organic Reducing Agent

Author(s) -

Abhishek Dewanji,

Raoul F. Bülow,

Magnus Rueping

Publication year - 2020

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.0c00199

Subject(s) - chemistry , aryl , halide , catalysis , nickel , combinatorial chemistry , reducing agent , coupling (piping) , coupling reaction , dual (grammatical number) , organic chemistry , photochemistry , alkyl , mechanical engineering , art , literature , engineering

A successful protocol for the reductive aryl-aryl cross-coupling of polyfluorinated arenes with a broad range of aryl halides has been developed. Sequential carbon-fluorine bond cleavage and carbon-carbon bond formation are two of the important features of the reaction. Addition of an aryl radical anion to a nickel intermediate was achieved for the first time using polyfluoroarenes as radical precursors. This, in combination with the excellen para selectivity, paves the way for the synthesis of various new multifluorinated biaryl compounds.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research