Electrochemical Intramolecular Oxytrifluoromethylation of N-Tethered Alkenyl Alcohols: Synthesis of Functionalized Morpholines | Zendy

Aurélie Claraz | Zendy; Thibaut Courant | Zendy; Géraldine Masson | Zendy

Open Access

Electrochemical Intramolecular Oxytrifluoromethylation of N-Tethered Alkenyl Alcohols: Synthesis of Functionalized Morpholines

Author(s) -

Aurélie Claraz,

Thibaut Courant,

Géraldine Masson

Publication year - 2020

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.0c00176

Subject(s) - chemistry , intramolecular force , reagent , electrochemistry , electrolysis , anode , combinatorial chemistry , organic chemistry , electrode , electrolyte

An electrochemical intramolecular oxytrifluoromethylation of N -tethered alkenyl alcohols was developed providing straightforward access to CF 3 -containing morpholines derivatives. The method features mild reaction conditions with direct anodic oxidation of Langlois reagent as a cheap and easy to handle trifluoromethylating reagent. Variously substituted 2-(2,2,2-trifluoroethyl)morpholines were obtained in moderate to high yields under constant current electrolysis in an undivided cell.

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