A Convenient Multigram Synthesis of DABSO Using Sodium Sulfite as SO2 Source | Zendy

Seger Van Mileghem | Zendy; Wim M. De Borggraeve | Zendy

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A Convenient Multigram Synthesis of DABSO Using Sodium Sulfite as SO₂ Source

Author(s) -

Seger Van Mileghem,

Wim M. De Borggraeve

Publication year - 2017

Publication title -

organic process research and development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.904

H-Index - 109

eISSN - 1520-586X

pISSN - 1083-6160

DOI - 10.1021/acs.oprd.7b00083

Subject(s) - anhydrous , sodium sulfite , chemistry , sulfite , sulfur dioxide , stoichiometry , yield (engineering) , sulfur , sodium , dabco , inorganic chemistry , organic chemistry , catalysis , materials science , metallurgy

A convenient synthesis of DABCOÂ·(SO2)2 (abbreviated as DABSO) is reported. Using a two-chamber set-up, sulfur dioxide is generated in one chamber and consumed in the other. This closed system overcomes safety issues related to working with toxic SO2 gas. Pressure build-up is avoided by gradually generating the gas using sodium sulfite as precursor. Moreover, only near-stoichiometric amounts of SO2 are required for this protocol. The use of anhydrous solvents is not necessary and every step is performed at room temperature. A scale-up was carried out on a 10 gram scale which, after overnight drying, resulted in a quantitative yield.status: publishe

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