Open AccessA Microflow Electrolysis Cell for Laboratory Synthesis on the Multigram Scale
Author(s) -
Robert A. Green,
Richard C. D. Brown,
Derek Pletcher,
Bashir H. Harji
Publication year - 2015
Publication title -
organic process research and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 109
eISSN - 1520-586X
pISSN - 1083-6160
DOI - 10.1021/acs.oprd.5b00260
Subject(s) - electrolysis , chemistry , electrolyte , selectivity , electrolytic cell , electrode , volumetric flow rate , scale up , flow chemistry , chemical engineering , analytical chemistry (journal) , combinatorial chemistry , chromatography , organic chemistry , catalysis , thermodynamics , physics , classical mechanics , engineering
A large microflow electrolysis cell for laboratory synthesis on a multigram scale is described. It is based on two circular electrodes with a diameter of 149 mm and a spiral electrolyte flow channel 2000 mm long, 5 mm wide, and 0.5 mm interelectrode gap. Using the methoxylation of N-formylpyrrolidine as a model reaction, it is demonstrated that the cell approaches 100% conversion in a single pass, and it is possible to achieve a reaction selectivity >95% and a product formation rate of >20 g h–1.
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