Nanobowl-Supported Liposomes Improve Drug Loading and Delivery | Zendy

Zhongjian Chen | Zendy; SiCong Yang | Zendy; Xueliang Liu | Zendy; Yuhao Gao | Zendy; Xiao Dong | Zendy; Xing Lai | Zendy; MaoHua Zhu | Zendy; HaiYi Feng | Zendy; XinDi Zhu | Zendy; Qin Lu | Zendy; Mei Zhao | Zendy; Hongzhuan Chen | Zendy; Jonathan F. Lovell | Zendy; Chao Fang | Zendy

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Nanobowl-Supported Liposomes Improve Drug Loading and Delivery

Author(s) -

Zhongjian Chen,

SiCong Yang,

Xueliang Liu,

Yuhao Gao,

Xiao Dong,

Xing Lai,

MaoHua Zhu,

HaiYi Feng,

XinDi Zhu,

Qin Lu,

Mei Zhao,

Hongzhuan Chen,

Jonathan F. Lovell,

Chao Fang

Publication year - 2020

Publication title -

nano letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.853

H-Index - 488

eISSN - 1530-6992

pISSN - 1530-6984

DOI - 10.1021/acs.nanolett.0c00495

Subject(s) - liposome , drug delivery , drug , doxorubicin , drug carrier , nanotechnology , targeted drug delivery , chemistry , materials science , biomedical engineering , pharmacology , chemotherapy , medicine , surgery

Liposomal drug delivery for cancer therapy can be limited due to drug leakage in circulation. Here, we develop a new method to enhance the stability of actively loaded liposomal doxorubicin (DOX) through embedding a stiff nanobowl in the liposomal water cavity. Nanobowl-supported liposomal DOX (DOX@NbLipo) resists the influence of plasma protein and blood flow shear force to prevent drug leakage. This approach yields improved drug delivery to tumor sites and enhanced antitumor efficacy. Compared to alternative methods of modifying liposome surface and composition for stability, this approach designs a physical support for an all-aqueous nanoliposomal cavity. Nanobowl stabilization of liposomes is a simple and effective method to improve carrier stability and drug delivery.

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