NMR Relaxometry to Characterize the Drug Structural Phase in a Porous Construct | Zendy

Linn W. Thrane | Zendy; Emily A. Berglund | Zendy; James N. Wilking | Zendy; D. Vodak | Zendy; Joseph D. Seymour | Zendy

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NMR Relaxometry to Characterize the Drug Structural Phase in a Porous Construct

Author(s) -

Linn W. Thrane,

Emily A. Berglund,

James N. Wilking,

D. Vodak,

Joseph D. Seymour

Publication year - 2018

Publication title -

molecular pharmaceutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.13

H-Index - 127

eISSN - 1543-8392

pISSN - 1543-8384

DOI - 10.1021/acs.molpharmaceut.8b00144

Subject(s) - relaxometry , phase (matter) , construct (python library) , porosity , drug , chemistry , materials science , medicine , magnetic resonance imaging , computer science , pharmacology , organic chemistry , radiology , spin echo , programming language

Nuclear magnetic resonance (NMR) frequency spectra and T 2 relaxation time measurements, using a high-power radio frequency probe, are shown to characterize the presence of an amorphous drug in a porous silica construct. The results indicate the ability of non-solid-state NMR methods to characterize crystalline and amorphous solid structural phases in drugs. Two-dimensional T 1 - T 2 magnetic relaxation time correlation experiments are shown to monitor the impact of relative humidity on the drug in a porous silica tablet.

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