Host–Guest Interaction at Molecular Interfaces: Binding of Cucurbit[7]uril on Ferrocenyl Self-Assembled Monolayers on Gold | Zendy

Qi Lin | Zendy; Huihui Tian | Zendy; Huibo Shao | Zendy; HuaZhong Yu | Zendy

Open Access

Host–Guest Interaction at Molecular Interfaces: Binding of Cucurbit[7]uril on Ferrocenyl Self-Assembled Monolayers on Gold

Author(s) -

Qi Lin,

Huihui Tian,

Huibo Shao,

HuaZhong Yu

Publication year - 2017

Publication title -

the journal of physical chemistry c

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.401

H-Index - 289

eISSN - 1932-7455

pISSN - 1932-7447

DOI - 10.1021/acs.jpcc.7b01135

Subject(s) - monolayer , supramolecular chemistry , chemistry , redox , ferrocene , dissociation constant , molecular recognition , binding constant , self assembled monolayer , molecular binding , cucurbituril , biomolecule , dissociation (chemistry) , crystallography , molecule , stereochemistry , binding site , inorganic chemistry , electrochemistry , organic chemistry , receptor , biochemistry , electrode

Ferrocene (Fc) encapsulated cucurbit[7]uril (CB[7]) supramolecular host-guest complex (Fc@CB[7]) as a synthetic recognition pair has been widely adapted for coupling biomolecules and nanomaterials due to its ultra-high binding affinity. In this paper, we have explored the binding of CB[7] on binary ferrocenylundecanethiolate/octanethiolate self-assembled monolayer on gold (FcC11S-/C8S-Au), a model system to deepen our understanding of host-guest chemistry at molecular interfaces. It has been shown that upon incubation with CB[7] solution, the redox behavior FcC11S-/C8S-Au changes remarkably, i.e., a new pair of peaks appeared at more positive potential with narrowed widths. The ease of quantitation of surface bound-redox species (Fc+/Fc and Fc+@CB[7]/ Fc@CB[7]) enabled us to determine the thermodynamic formation constant of Fc@CB[7] at FcC11S-/C8S-Au (7.3±1.8 × 104 M-1). With time-dependent redox responses, we were able to, for the first time, deduce both the binding and dissociation rate constants, 2.8±0.3 × 103 M-1s-1 and 0.08±0.01 s-1, respectively. These results showed substantial differences both thermodynamically and kinetically for the formation of host-guest inclusion complex at molecular interfaces with respect to solution-diffused, homogenous environments

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