English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Although nanoparticle multivalency is known to influence their biological labeling performance, the functional role of multivalency is largely unexplored. Here we show that the folate receptor mediated cellular internalization mechanism of 35–50 nm nanoparticle shifts from caveolae- to clathrin-mediated endocytosis as the nanoparticle multivalency increases from 10 to 40 and results in the difference of their subcellular trafficking. We have synthesized folate functionalized multivalent quantum dot (QD) with varied average numbers of folate per QD between 10 and 110 [e.g., QD(folate)10, QD(folate)20, QD(folate)40, QD(folate)110] and investigated their uptake and localization into folate receptor overexpressed HeLa and KB cells. We found that uptake of QD(folate)10 occurs predominantly via caveolae-mediated endocytosis and entirely trafficked to the perinuclear region. In contrast, uptake of QD(folate)20 occurs via both caveolae- and chathrin-mediated endocytosis; uptake of QD(folate)40 and QD(folate)110 o...

Nanoparticle Multivalency Directed Shifting of Cellular Uptake Mechanism