Is the Use of Surface-Enhanced Infrared Spectroscopy Justified in the Selection of Peptide Fragments That Play a Role in Substrate–Receptor Interactions? Adsorption of Amino Acids and Neurotransmitters on Colloidal Ag and Au Nanoparticles | Zendy

Leonard M. Proniewicz | Zendy; Agnieszka Tąta | Zendy; Emilia Iłowska | Zendy; Adam Prahl | Zendy

Open Access

Is the Use of Surface-Enhanced Infrared Spectroscopy Justified in the Selection of Peptide Fragments That Play a Role in Substrate–Receptor Interactions? Adsorption of Amino Acids and Neurotransmitters on Colloidal Ag and Au Nanoparticles

Author(s) -

Leonard M. Proniewicz,

Agnieszka Tąta,

Emilia Iłowska,

Adam Prahl

Publication year - 2021

Publication title -

the journal of physical chemistry b

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.864

H-Index - 392

eISSN - 1520-6106

pISSN - 1520-5207

DOI - 10.1021/acs.jpcb.1c00546

Subject(s) - infrared spectroscopy , attenuated total reflection , fourier transform infrared spectroscopy , chemistry , peptide , bombesin , spectroscopy , silver nanoparticle , amino acid , molecule , colloidal gold , adsorption , substrate (aquarium) , infrared , nanoparticle , analytical chemistry (journal) , materials science , receptor , biochemistry , organic chemistry , chemical engineering , nanotechnology , biology , neuropeptide , ecology , physics , quantum mechanics , optics , engineering

This paper describes an application of attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and surface-enhanced infrared spectroscopy (SEIRA) to characterize the selective adsorption of four peptides present in body fluids such as neuromedin B (NMB), bombesin (BN), neurotensin (NT), and bradykinin (BK), which are known as markers for various human carcinomas. To perform a reliable analysis of the SERIA spectra of these peptides, curve fitting of these spectra in the spectral region above 1500 cm –1 and SEIRA measurements of sulfur-containing and aromatic amino acids were performed. On the basis of the analyses of the spectral profiles, specific conclusions were drawn regarding specific molecule–metal interactions and changes in the interaction during the substrate change from the surface of silver nanoparticles (AgNPs) to gold nanoparticles (AuNPs).

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