Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling | Zendy

Malvika Sardana | Zendy; Joakim Bergman | Zendy; Cecilia Ericsson | Zendy; Lee Kingston | Zendy; Magnus Schou | Zendy; Christophe Dugave | Zendy; Davide Audisio | Zendy; Charles S. Elmore | Zendy

Open Access

Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling

Author(s) -

Malvika Sardana,

Joakim Bergman,

Cecilia Ericsson,

Lee Kingston,

Magnus Schou,

Christophe Dugave,

Davide Audisio,

Charles S. Elmore

Publication year - 2019

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/acs.joc.9b02575

Subject(s) - alkyl , carbon monoxide , chemistry , stoichiometry , catalysis , carbonylation , palladium , organic chemistry

A visible-light-mediated late-stage aminocarbonylation of unactivated alkyl iodides with stoichiometric amounts of carbon monoxide is presented. The method provides a mild, one-step route to [ carbonyl - 13/14 C] alkyl amides, thereby reducing radioactive waste, and handling of radioactive materials. Easily accessible and low-cost equipment and a palladium catalyst were successfully used for the synthesis of a wide range of alkyl amides.

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