Manganese-Catalyzed N-Alkylation of Sulfonamides Using Alcohols | Zendy

Benjamin G. ReedBerendt | Zendy; Louis C. Morrill | Zendy

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Manganese-Catalyzed N-Alkylation of Sulfonamides Using Alcohols

Author(s) -

Benjamin G. ReedBerendt,

Louis C. Morrill

Publication year - 2019

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/acs.joc.9b00203

Subject(s) - alkylation , manganese , chemistry , catalysis , yield (engineering) , alkyl , aryl , pincer movement , primary (astronomy) , organic chemistry , combinatorial chemistry , materials science , physics , astronomy , metallurgy

An efficient manganese-catalyzed N-alkylation of sulfonamides has been developed. This borrowing hydrogen approach employs a well-defined and bench-stable Mn(I) PNP pincer precatalyst, allowing benzylic and simple primary aliphatic alcohols to be employed as alkylating agents. A diverse range of aryl and alkyl sulfonamides undergoes mono- N-alkylation in excellent isolated yields (32 examples, 85% average yield).

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