Transfer of Sequence Information and Replication of Diimine Duplexes | Zendy

Kyle R. Strom | Zendy; Jack W. Szostak | Zendy; Noam Prywes | Zendy

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Transfer of Sequence Information and Replication of Diimine Duplexes

Author(s) -

Kyle R. Strom,

Jack W. Szostak,

Noam Prywes

Publication year - 2019

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/acs.joc.9b00095

Subject(s) - sequence (biology) , base pair , chemistry , covalent bond , dimer , dna , template , stereochemistry , combinatorial chemistry , biochemistry , nanotechnology , materials science , organic chemistry

The ability of the biopolymers RNA and DNA to store and transfer information is essential to life. Herein, we demonstrate template-directed replication in a set of dimer duplexes that use reversible covalent bonds to form base-pairing interactions. Binary sequence information was encoded as a sequence of aniline and benzaldehyde subunits linked together by a diethynyl benzene backbone. These dimers formed sequence-specific, imine-linked duplexes, which could be separated and used as templates for the synthesis of daughter duplexes with identical sequences.

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