A Unified Approach to the Isomeric α-, β-, γ-, and δ-Carbolines via their 6,7,8,9-Tetrahydro Counterparts | Zendy

Qiao Yan | Zendy; Emma Gin | Zendy; Martin G. Banwell | Zendy; Anthony C. Willis | Zendy; Paul D. Carr | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A Unified Approach to the Isomeric α-, β-, γ-, and δ-Carbolines via their 6,7,8,9-Tetrahydro Counterparts

Author(s) -

Qiao Yan,

Emma Gin,

Martin G. Banwell,

Anthony C. Willis,

Paul D. Carr

Publication year - 2017

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/acs.joc.7b00323

Subject(s) - chemistry , combinatorial chemistry , coupling (piping) , palladium , coupling reaction , computational chemistry , catalysis , organic chemistry , mechanical engineering , engineering

A cross-coupling/reductive cyclization protocol has been employed in a unified approach to all four carbolines. So, for example, the 2-nitropyridine 8, which is readily prepared through an efficient palladium-catalyzed Ullmann cross-coupling reaction, is reductively cyclized under conventional conditions to give 6,7,8,9-tetrahydro-α-carboline that is itself readily aromatized to give α-carboline (1).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research