Readily Accessible Unsymmetrical Unsaturated 2,6-Diisopropylphenyl N-Heterocyclic Carbene Ligands. Applications in Enantioselective Catalysis | Zendy

Robert Tarrieu | Zendy; Adrien Dumas | Zendy; Jompol Thongpaen | Zendy; Thomas Vivès | Zendy; Thierry Roisnel | Zendy; Vincent Dorcet | Zendy; Christophe Crévisy | Zendy; Olivier Baslé | Zendy; Marc Mauduit | Zendy

Open Access

Readily Accessible Unsymmetrical Unsaturated 2,6-Diisopropylphenyl N-Heterocyclic Carbene Ligands. Applications in Enantioselective Catalysis

Author(s) -

Robert Tarrieu,

Adrien Dumas,

Jompol Thongpaen,

Thomas Vivès,

Thierry Roisnel,

Vincent Dorcet,

Christophe Crévisy,

Olivier Baslé,

Marc Mauduit

Publication year - 2017

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/acs.joc.6b02888

Subject(s) - enantioselective synthesis , carbene , catalysis , chemistry , combinatorial chemistry , organic chemistry

A new multicomponent procedure was applied to the synthesis of (a)chiral bulky unsymmetrical unsaturated 2,6-diisopropylphenyl N-heterocyclic carbene (NHC) precursors with excellent selectivity (up to 95%) and good yields. This approach offers access to new chiral NHC ligands, which have found successful applications in both copper-catalyzed asymmetric allylic alkylation and copper-catalyzed asymmetric borylation.

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