Synthesis of α-Quaternized 2,4-Cyclohexadienones from Propargyl Vinyl Ethers | Zendy

David Tejedor | Zendy; Samuel DelgadoHernández | Zendy; Mariana Ingold | Zendy; Fernando GarcíaTellado | Zendy

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Synthesis of α-Quaternized 2,4-Cyclohexadienones from Propargyl Vinyl Ethers

Author(s) -

David Tejedor,

Samuel DelgadoHernández,

Mariana Ingold,

Fernando GarcíaTellado

Publication year - 2016

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/acs.joc.6b02137

Subject(s) - chemistry , propargyl , domino , imidazole , catalysis , carbon atom , organic chemistry , combinatorial chemistry , ring (chemistry)

A microwave-assisted and base-catalyzed domino manifold to construct 2,4-cyclohexadienone derivatives has been implemented. The domino manifold uses easily accessible tertiary propargyl vinyl ethers bearing a methine group at the homopropargylic position and imidazole as the catalyst to deliver 2,4-cyclohexadienones featuring a key formyl group and a quaternized carbon atom in good yields.

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