Synthesis of Substituted 3(2H)-Furanones Using Alkylative Intramolecular Cyclization of Sulfonium Salts
Author(s) -
Sho Inagaki,
Mika Ukaku,
Akira Chiba,
Fumi Takahashi,
Yasuharu Yoshimi,
Toshio Morita,
Tomikazu Kawano
Publication year - 2016
Publication title -
the journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.2
H-Index - 228
eISSN - 1520-6904
pISSN - 0022-3263
DOI - 10.1021/acs.joc.6b01528
Subject(s) - chemistry , sulfonium , intramolecular force , alkylation , intramolecular reaction , combinatorial chemistry , organic chemistry , medicinal chemistry , salt (chemistry) , catalysis
The facile alkylative intramolecular cyclization of 3-alkoxycarbonyl-2-oxopropyldiphenylsulfonium salts is described. This simple method can be readily applied to the synthesis of a novel family of 4-alkylated 3(2H)-furanones in moderate to high yields under mild conditions via a one-pot process.
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