Open AccessIridium-Catalyzed Direct Synthesis of Tryptamine Derivatives from Indoles: Exploiting N-Protected β-Amino Alcohols as Alkylating Agents
Author(s) -
Silvia Bartolucci,
Michele Mari,
Annalida Bedini,
Giovanni Piersanti,
Gilberto Spadoni
Publication year - 2015
Publication title -
the journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.2
H-Index - 228
eISSN - 1520-6904
pISSN - 0022-3263
DOI - 10.1021/acs.joc.5b00195
Subject(s) - chemistry , tryptamine , iridium , catalysis , indole test , combinatorial chemistry , organic chemistry , biochemistry
The selective C3-alkylation of indoles with N-protected ethanolamines involving the "borrowing hydrogen" strategy is described. This method provides convenient and sustainable access to several tryptamine derivatives.
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