Synthesis of Azacarbolines via PhIO2-Promoted Intramolecular Oxidative Cyclization of α-Indolylhydrazones | Zendy

Matteo Corrieri | Zendy; Lucia De Crescentini | Zendy; Fabio Mantellini | Zendy; Giacomo Mari | Zendy; Stefania Santeusanio | Zendy; Gianfranco Favi | Zendy

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Synthesis of Azacarbolines via PhIO₂-Promoted Intramolecular Oxidative Cyclization of α-Indolylhydrazones

Author(s) -

Matteo Corrieri,

Lucia De Crescentini,

Fabio Mantellini,

Giacomo Mari,

Stefania Santeusanio,

Gianfranco Favi

Publication year - 2021

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/acs.joc.1c02217

Subject(s) - chemistry , trifluoroacetic acid , intramolecular force , oxidative phosphorylation , inert gas , indole test , inert , transition metal , transformation (genetics) , oxidative coupling of methane , combinatorial chemistry , atmosphere (unit) , organic chemistry , medicinal chemistry , catalysis , biochemistry , physics , thermodynamics , gene

An unprecedented synthesis of polysubstituted indole-fused pyridazines (azacarbolines) from α-indolylhydrazones under oxidative conditions using a combination of iodylbenzene (PhIO 2 ) and trifluoroacetic acid (TFA) has been developed. This transformation is conducted without the need for transition metals, harsh conditions, or an inert atmosphere.

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