Enantioselective α-Arylation of Primary Alcohols under Sequential One-Pot Catalysis | Zendy

Bruno Lainer | Zendy; Dawid Lichosyt | Zendy; Maiia I. Aleksandrova | Zendy; Paweł Dydio | Zendy

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Enantioselective α-Arylation of Primary Alcohols under Sequential One-Pot Catalysis

Author(s) -

Bruno Lainer,

Dawid Lichosyt,

Maiia I. Aleksandrova,

Paweł Dydio

Publication year - 2021

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/acs.joc.1c00983

Subject(s) - chemistry , enantioselective synthesis , nucleophile , primary (astronomy) , aryl , catalysis , organic chemistry , combinatorial chemistry , halide , tertiary alcohols , alkyl , physics , astronomy

Secondary benzylic alcohols and diarylmethanols are common structural motifs of biologically active and medicinally relevant compounds. Here we report their enantioselective synthesis by α-arylation of primary aliphatic and benzylic alcohols under sequential catalysis integrating a Ru-catalyzed hydrogen transfer oxidation and a Ru-catalyzed nucleophilic addition. The method can be applied to various alcohols and aryl nucleophiles tolerating a range of functional groups, including secondary alcohols, ketones, alkenes, esters, NH amides, tertiary amines, aryl halides, and heterocycles.

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