Open AccessMetal-Free Addition of Benzyl Halides to Aldehydes Using Super Electron Donors: Access to 3,4-Dihydroisocoumarins and 1,2-Diarylethanols
Author(s) -
Cédric Spitz,
Mélanie Matteudi,
Guillaume Tintori,
Julie Broggi,
Thierry Terme,
Patrice Vanelle
Publication year - 2020
Publication title -
the journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.2
H-Index - 228
eISSN - 1520-6904
pISSN - 0022-3263
DOI - 10.1021/acs.joc.0c02374
Subject(s) - chemistry , halide , metal , intermolecular force , medicinal chemistry , organic chemistry , molecule
We report here the intermolecular metal-free addition reaction of functionalized benzyl halides to aldehydes using a super electron donor (SED). The metal-free and mild conditions allowed the formation of 3,4-dihydroisocoumarins and 1,2-diarylethanols with unprecedented functional group tolerance.
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