Synthesis of Sulfonamide-Based Ynamides and Ynamines in Water | Zendy

Lei Zhao | Zendy; Hongyi Yang | Zendy; Ruikun Li | Zendy; Ye Tao | Zendy; Xiaofeng Guo | Zendy; Edward A. Anderson | Zendy; Andrew Whiting | Zendy; Na Wu | Zendy

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Synthesis of Sulfonamide-Based Ynamides and Ynamines in Water

Author(s) -

Lei Zhao,

Hongyi Yang,

Ruikun Li,

Ye Tao,

Xiaofeng Guo,

Edward A. Anderson,

Andrew Whiting,

Na Wu

Publication year - 2020

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/acs.joc.0c02326

Subject(s) - chemistry , sonogashira coupling , sulfonamide , ammonium , pulmonary surfactant , salt (chemistry) , combinatorial chemistry , water soluble , moisture , organic chemistry , catalysis , palladium , biochemistry

Ynamides, though relatively more stable than ynamines, are still moisture-sensitive and prone to hydration especially under acidic and heating conditions. Here we report an environmentally benign, robust protocol to synthesize sulfonamide-based ynamides and arylynamines via Sonogashira coupling reactions in water, using a readily available quaternary ammonium salt as the surfactant.

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