Synthetic Access to Hydrophilic Tetramate Derivatives of Cysteine | Zendy

Ruirui Zhang | Zendy; Xiang Li | Zendy; Miroslav Genov | Zendy; Alexander Pretsch | Zendy; Dagmar Pretsch | Zendy; Mark G. Moloney | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Synthetic Access to Hydrophilic Tetramate Derivatives of Cysteine

Author(s) -

Ruirui Zhang,

Xiang Li,

Miroslav Genov,

Alexander Pretsch,

Dagmar Pretsch,

Mark G. Moloney

Publication year - 2020

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/acs.joc.0c01636

Subject(s) - chemistry , combinatorial chemistry , cysteine , bicyclic molecule , chelation , chemical synthesis , antibacterial activity , organic chemistry , stereochemistry , bacteria , in vitro , biochemistry , biology , genetics , enzyme

The synthesis, structural, and antibacterial evaluation of bicyclic tetramate derivatives of cysteine rendered hydrophilic with pendant heterocyclic substituents is reported; effective synthetic protocols and antibacterial activity for a small library of polar derivatives were found, and direct evidence for strong metal chelation in these systems was obtained. A computational study has developed a detailed understanding of the controlling factors of the key Dieckmann cyclization step.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research