Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors | Zendy

LaureAnne Peyrat | Zendy; Véronique Éparvier | Zendy; Cécilia Eydoux | Zendy; JeanClaude Guillemot | Zendy; Marc Litaudon | Zendy; Didier Stien | Zendy

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Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors

Author(s) -

LaureAnne Peyrat,

Véronique Éparvier,

Cécilia Eydoux,

JeanClaude Guillemot,

Marc Litaudon,

Didier Stien

Publication year - 2020

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/acs.jnatprod.9b01169

Subject(s) - dengue virus , flavivirus , dengue fever , phomopsis , biology , virology , endophyte , polymerase , virus , cytotoxicity , chemistry , stereochemistry , biochemistry , microbiology and biotechnology , botany , in vitro , enzyme

Thirteen carneic acids were isolated from the fungal endophyte Phomopsis sp. SNB-LAP1-7-32. Their structures were identified by mass spectrometry and extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. Compounds 1 - 13 were investigated for their antipolymerase activities against DENV polymerase and Zika NS5. Five of them exhibited significant inhibition of dengue polymerase with IC 50 values in the 10 to 20 μM range without cytotoxicity. None inhibited Zika virus NS5 protein.

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