Antioxidant Activity of Compounds Isolated from Elaeagnus umbellata Promotes Human Gingival Fibroblast Well-Being | Zendy

Anna Maria Iannuzzi | Zendy; Chiara Giacomelli | Zendy; Marinella De Leo | Zendy; Deborah Pietrobono | Zendy; Fabiano Camangi | Zendy; Nunziatina De Tommasi | Zendy; Claudia Martini | Zendy; Maria Letizia Trincavelli | Zendy; Alessandra Braca | Zendy

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Antioxidant Activity of Compounds Isolated from Elaeagnus umbellata Promotes Human Gingival Fibroblast Well-Being

Author(s) -

Anna Maria Iannuzzi,

Chiara Giacomelli,

Marinella De Leo,

Deborah Pietrobono,

Fabiano Camangi,

Nunziatina De Tommasi,

Claudia Martini,

Maria Letizia Trincavelli,

Alessandra Braca

Publication year - 2020

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/acs.jnatprod.9b01030

Subject(s) - chemistry , antioxidant , fibroblast , cell growth , glucoside , biochemistry , stereochemistry , in vitro , medicine , alternative medicine , pathology

Four new triterpenoid bidesmosidic saponins ( 1 - 4 ) and a sesquiterpenoid glucoside ( 5 ), together with nine known phenolic compounds ( 6 - 14 ), were isolated from the fruits of Elaeagnus umbellata . Their structures were elucidated using 1D and 2D NMR spectroscopy and mass spectrometry data. The antioxidant capability of the isolated compounds was evaluated in human gingival fibroblasts. Compound 6 decreased ROS production and promoted cell proliferation. It also counteracted the cell cycle blockade induced by a low concentration of H 2 O 2 decreasing the expression of p21 and CDKN2A (p16 INK4A ). Compound 6 decreased the expression of inflammatory cytokines (IL-6 and IL-8) in response to inflammatory stimuli, supporting its possible use in periodontitis lesions.

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