Structural Characterization and Anti-infective Activity of 9,10-Seco-29-norcycloartane Glycosides Isolated from the Flowers of the Peruvian Medicinal Plant Cordia lutea | Zendy

Inés Castro | Zendy; Nicolás Fabre | Zendy; Sandra BourgeadeDelmas | Zendy; N. Saffon | Zendy; Chloé Gandini | Zendy; Michel Sauvain | Zendy; Denis Castillo | Zendy; Geneviève Bourdy | Zendy; Valérie Jullian | Zendy

Open Access

Structural Characterization and Anti-infective Activity of 9,10-Seco-29-norcycloartane Glycosides Isolated from the Flowers of the Peruvian Medicinal Plant Cordia lutea

Author(s) -

Inés Castro,

Nicolás Fabre,

Sandra BourgeadeDelmas,

N. Saffon,

Chloé Gandini,

Michel Sauvain,

Denis Castillo,

Geneviève Bourdy,

Valérie Jullian

Publication year - 2019

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/acs.jnatprod.9b00149

Subject(s) - glycoside , antibacterial activity , pharmacognosy , staphylococcus aureus , in vitro , stereochemistry , traditional medicine , cytotoxicity , bioassay , escherichia coli , chemistry , medicinal plants , biology , fractionation , biological activity , lactone , terpenoid , bacteria , botany , biochemistry , organic chemistry , medicine , genetics , gene

Six new secocycloartane glycosides ( 1 - 6 ) were isolated from the ethanol extract of the flowers of Cordia lutea Lam. on the basis of bioassay-guided fractionation. Their structures were determined by the application of NMR and MS data analyses together with X-ray crystallographic analyses for compounds 1 and 2 . Compounds 1 - 6 represent the first examples of 9,10-seco-29-norcycloartane glycosides. These compounds showed significant in vitro anti- Helicobacter pylori activity, and no activity against either Escherichia coli or Pseudomonas aeruginosa . Significant activity was observed for 5 and 6 agains Staphylococcus aureus . All compounds displayed weak cytotoxicity against RAW 264.7 cells. The in vitro antileishmanial and antiplasmodial activities of 1 - 6 were also evaluated.

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