Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima | Zendy

Santana A.L. Thomas | Zendy; Jacqueline L. von Salm | Zendy; Shane Clark | Zendy; Steve Ferlita | Zendy; Prasanth Nemani | Zendy; Ala Azhari | Zendy; Christopher A. Rice | Zendy; Nerida G. Wilson | Zendy; Dennis E. Kyle | Zendy; Bill J. Baker | Zendy

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Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima

Author(s) -

Santana A.L. Thomas,

Jacqueline L. von Salm,

Shane Clark,

Steve Ferlita,

Prasanth Nemani,

Ala Azhari,

Christopher A. Rice,

Nerida G. Wilson,

Dennis E. Kyle,

Bill J. Baker

Publication year - 2017

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/acs.jnatprod.7b00732

Subject(s) - diterpene , stereochemistry , terpene , cytotoxicity , coral , chemistry , terpenoid , mass spectrometry , biology , biochemistry , ecology , in vitro , chromatography

During a 2013 cruise in the Southern Ocean we collected specimens of the octocoral Plumarella delicatissima between 800 and 950 m depth. Five new furanocembranoid diterpenes, keikipukalides A-E (1-5), the known diterpene pukalide aldehyde (6), and the known norditerpenoid ineleganolide (7) were isolated from the coral. These Plumarella terpenes lack mammalian cytotoxicity, while 2-7 display activity against Leishmania donovani between 1.9 and 12 μM. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy and mass spectrometry, and keikipukalides A and E were confirmed by X-ray crystallography.

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