Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cellsin Vitroand Reduces Neointima Formationin Vivo | Zendy

Rongxia Liu | Zendy; Elke H. Heiß | Zendy; Daniel Schachner | Zendy; Baohong Jiang | Zendy; Wanhui Liu | Zendy; Johannes M. Breuss | Zendy; Verena M. Dirsch | Zendy; Atanas G. Atanasov | Zendy

Open Access

Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cellsin Vitroand Reduces Neointima Formationin Vivo

Author(s) -

Rongxia Liu,

Elke H. Heiß,

Daniel Schachner,

Baohong Jiang,

Wanhui Liu,

Johannes M. Breuss,

Verena M. Dirsch,

Atanas G. Atanasov

Publication year - 2017

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/acs.jnatprod.7b00268

Subject(s) - neointima , vascular smooth muscle , in vivo , xanthohumol , platelet derived growth factor receptor , microbiology and biotechnology , in vitro , cell growth , platelet derived growth factor , chemistry , biology , growth factor , pharmacology , biochemistry , medicine , endocrinology , smooth muscle , restenosis , ecology , receptor , key (lock) , stent

Xanthohumol (1) is a principal prenylated chalcone found in hops. The aim of this study was to examine its influence on platelet-derived growth factor (PDGF)-BB-triggered vascular smooth muscle cell (VSMC) proliferation and migration in vitro and on experimentally induced neointima formation in vivo. Quantification of resazurin conversion indicated that 1 can inhibit PDGF-BB-induced VSMC proliferation concentration-dependently (IC 50 = 3.49 μM). Furthermore, in a wound-healing assay 1 potently suppresses PDGF-BB-induced VSMC migration at 15 μM. Tested in a mouse femoral artery cuff model, 1 significantly reduces neointima formation. Taken together, we show that 1 represses PDGF-BB-induced VSMC proliferation and migration in vitro as well as neointima formation in vivo. This novel activity suggests 1 as an interesting candidate for further studies addressing a possible therapeutic application to counteract vascular proliferative disease.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research