Nepetaefolins A–J, Cytotoxic Chinane and Abietane Diterpenoids from Caryopteris nepetaefolia | Zendy

Chenggang Zhang | Zendy; GuiXin Chou | Zendy; Xu-Dong Mao | Zendy; Qingshan Yang | Zendy; JianLi Zhou | Zendy

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Nepetaefolins A–J, Cytotoxic Chinane and Abietane Diterpenoids from Caryopteris nepetaefolia

Author(s) -

Chenggang Zhang,

GuiXin Chou,

Xu-Dong Mao,

Qingshan Yang,

JianLi Zhou

Publication year - 2017

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/acs.jnatprod.6b00972

Subject(s) - abietane , cytotoxicity , stereochemistry , cytotoxic t cell , chemistry , paclitaxel , ic50 , diterpene , in vitro , biology , biochemistry , cancer , genetics

Nepetaefolins A-J (1-10) and seven known compounds were isolated from the whole plant of Caryopteris nepetaefolia. The absolute configurations of 1-3 were determined from single-crystal X-ray diffraction and spectroscopic data. Compounds 6 and 7, with IC 50 values of 6.3-9.0 μM, showed higher cytotoxicity than paclitaxel in one non-small-cell lung cancer, patient-derived xenograft (PDX) model when tested using PDX models and the adenosine triphosphate-tumor chemosensitivity assay (ATP-TCA).

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