Antimicrobial Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus | Zendy

Yi Zang | Zendy; Grégory GentaJouve | Zendy; Alexandre E. Escargueil | Zendy; Annette K. Larsen | Zendy; Laura Guédon | Zendy; Bastien Nay | Zendy; Soizic Prado | Zendy

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Antimicrobial Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus

Author(s) -

Yi Zang,

Grégory GentaJouve,

Alexandre E. Escargueil,

Annette K. Larsen,

Laura Guédon,

Bastien Nay,

Soizic Prado

Publication year - 2016

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/acs.jnatprod.6b00458

Subject(s) - antimicrobial , fungus , circular dichroism , hela , absolute configuration , stereochemistry , polyketide , cytotoxicity , chemistry , bacteria , microbiology and biotechnology , biology , biochemistry , organic chemistry , botany , in vitro , enzyme , biosynthesis , genetics

New polyketide-derived oligophenalenone dimers, 9a-epi-bacillisporin E (1) and bacillisporins F-H (2-5), along with the known bacillisporin A (6), were isolated from the fungus Talaromyces stipitatus. Their structures and absolute configurations were determined on the basis of spectroscopic analyses, electronic circular dichroism, and GIAO NMR shift calculation followed by DP4 analysis. The antimicrobial activity of these compounds was evaluated against a panel of human pathogenic bacteria. Among them, bacillisporin H (5) exhibited antimicrobial activity together with modest cytotoxicity against HeLa cells.

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