Identification of 6-Hydroxymellein Synthase and Accessory Genes in the Lichen Cladonia uncialis | Zendy

Mona AbdelHameed | Zendy; Robert L. Bertrand | Zendy; Michele D. PierceyNormore | Zendy; John L. Sorensen | Zendy

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Identification of 6-Hydroxymellein Synthase and Accessory Genes in the Lichen Cladonia uncialis

Author(s) -

Mona AbdelHameed,

Robert L. Bertrand,

Michele D. PierceyNormore,

John L. Sorensen

Publication year - 2016

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/acs.jnatprod.6b00257

Subject(s) - polyketide synthase , gene cluster , gene , homology (biology) , biology , genetics , aspergillus terreus , genome , nucleic acid sequence , atp synthase , polyketide , biosynthesis , biochemistry

A transcribed polyketide synthase (PKS) gene has been identified in the lichen Cladonia uncialis. The complete nucleotide sequence of this PKS was determined from the amplified cDNA, and an assignment of individual domains was accomplished by homology searching using AntiSMASH. A scan of the complete genome sequence of C. uncialis revealed the accessory genes associated with this PKS gene. A homology search has identified that several genes in this cluster are similar to genes responsible for the biosynthesis of terrein in Aspergillus terreus. This permitted assignment of putative function to each of the genes in this new C. uncialis cluster. It is proposed that this gene cluster is responsible for the biosynthesis of a halogenated iscoumarin. This is the first report linking a gene cluster to a halogenated metabolite in lichen.

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