C3 and 2D C3 Marfey’s Methods for Amino Acid Analysis in Natural Products | Zendy

Soumini Vijayasarathy | Zendy; Pritesh Prasad | Zendy; Leith J. Fremlin | Zendy; Ranjala Ratnayake | Zendy; Angela A. Salim | Zendy; Zeinab G. Khalil | Zendy; Robert J. Capon | Zendy

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C₃ and 2D C₃ Marfey’s Methods for Amino Acid Analysis in Natural Products

Author(s) -

Soumini Vijayasarathy,

Pritesh Prasad,

Leith J. Fremlin,

Ranjala Ratnayake,

Angela A. Salim,

Zeinab G. Khalil,

Robert J. Capon

Publication year - 2016

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/acs.jnatprod.5b01125

Subject(s) - amino acid , enantiomer , regioselectivity , chemistry , stereochemistry , resolution (logic) , combinatorial chemistry , organic chemistry , computer science , biochemistry , artificial intelligence , catalysis

We validate the improved resolution and sensitivity of the C3 Marfey's method, including an ability to resolve all Ile isomers, against an array of amino acids commonly encountered in natural products and by comparison to an existing Marfey's method. We also describe an innovative 2D C3 Marfey's method as an analytical approach for determining the regiochemistry of enantiomeric amino acid residues in natural products. The C3 and 2D C3 Marfey's methods represent valuable tools for probing and defining the stereocomplexity of hydrolytically accessible amino acid residues in natural products.

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