Pinofuranoxins A and B, Bioactive Trisubstituted Furanones Produced by the Invasive Pathogen Diplodia sapinea | Zendy

Marco Masi | Zendy; Roberta Di Lecce | Zendy; Giulia Marsico | Zendy; Benedetto Teodoro Linaldeddu | Zendy; Lucia Maddau | Zendy; Stefano Superchi | Zendy; Antonio Evidente | Zendy

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Pinofuranoxins A and B, Bioactive Trisubstituted Furanones Produced by the Invasive Pathogen Diplodia sapinea

Author(s) -

Marco Masi,

Roberta Di Lecce,

Giulia Marsico,

Benedetto Teodoro Linaldeddu,

Lucia Maddau,

Stefano Superchi,

Antonio Evidente

Publication year - 2021

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/acs.jnatprod.1c00365

Subject(s) - circular dichroism , biology , botany , phaseolus , two dimensional nuclear magnetic resonance spectroscopy , stereochemistry , artemia salina , absolute configuration , hedera helix , chemistry , biochemistry , organic chemistry , toxicity

Two new bioactive trisubstituted furanones, named pinofuranoxins A and B ( 1 and 2 ), were isolated from Diplodia sapinea , a worldwide conifer pathogen causing severe disease. Pinofuranoxins A and B were characterized essentially by NMR and HRESIMS spectra, and their relative and absolute configurations were assigned by NOESY experiments and computational analyses of electronic circular dichroism spectra. They induced necrotic lesions on Hedera helix L., Phaseolus vulgaris L., and Quercus ilex L. Compound 1 completely inhibited the growth of Athelia rolfsii and Phytophthora cambivora , while 2 showed antioomycetes activity against P. cambivora . In the Artemia salina assay both toxins showed activity inducing larval mortality.

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