Biflavanones, Chalconoids, and Flavonoid Analogues from the Stem Bark of Ochna holstii | Zendy

Thobias M. Kalenga | Zendy; Monica M. Ndoile | Zendy; Yoseph Atilaw | Zendy; Pieter J. Gilissen | Zendy; Joan J. E. Munissi | Zendy; Anastasia Rudenko | Zendy; Catarina Bourgard | Zendy; Per Sunnerhagen | Zendy; Stephen S. Nyandoro | Zendy; Máté Erdélyi | Zendy

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Biflavanones, Chalconoids, and Flavonoid Analogues from the Stem Bark of Ochna holstii

Author(s) -

Thobias M. Kalenga,

Monica M. Ndoile,

Yoseph Atilaw,

Pieter J. Gilissen,

Joan J. E. Munissi,

Anastasia Rudenko,

Catarina Bourgard,

Per Sunnerhagen,

Stephen S. Nyandoro,

Máté Erdélyi

Publication year - 2021

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/acs.jnatprod.0c01017

Subject(s) - flavonoid , cytotoxicity , antibacterial activity , bacillus subtilis , ec50 , bark (sound) , pharmacognosy , chemistry , traditional medicine , stereochemistry , escherichia coli , bacteria , biology , in vitro , biological activity , biochemistry , medicine , ecology , antioxidant , gene , genetics

Two new biflavanones ( 1 and 2 ), three new bichalconoids ( 3 - 5 ), and 11 known flavonoid analogues ( 6 - 16 ) were isolated from the stem bark extract (CH 3 OH-CH 2 Cl 2 , 7:3, v/v) of Ochna holstii . The structures of the isolated metabolites were elucidated by NMR spectroscopic and mass spectrometric analyses. The crude extract and the isolated metabolites were evaluated for antibacterial activity against Bacillus subtilis (Gram-positive) and Escherichia coli (Gram-negative) as well as for cytotoxicity against the MCF-7 human breast cancer cell line. The crude extract and holstiinone A ( 1 ) exhibited moderate antibacterial activity against B. subtilis with MIC values of 9.1 μg/mL and 14 μM, respectively. The crude extract and lophirone F ( 14 ) showed cytotoxicity against MCF-7 with EC 50 values of 11 μg/mL and 24 μM, respectively. The other isolated metabolites showed no significant antibacterial activities (MIC > 250 μM) and cytotoxicities (EC 50 ≥ 350 μM).

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