Prenylated Flavonoids from the Roots of Tephrosia rhodesica | Zendy

Yoseph Atilaw | Zendy; Lois Muiva-Mutisya | Zendy; Jonathan Bogaerts | Zendy; Sandra Duffy | Zendy; Arto Valkonen | Zendy; Matthias Heydenreich | Zendy; Vicky M. Avery | Zendy; Kari Rissanen | Zendy; Máté Erdélyi | Zendy; Abiy Yenesew | Zendy

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Prenylated Flavonoids from the Roots of Tephrosia rhodesica

Author(s) -

Yoseph Atilaw,

Lois Muiva-Mutisya,

Jonathan Bogaerts,

Sandra Duffy,

Arto Valkonen,

Matthias Heydenreich,

Vicky M. Avery,

Kari Rissanen,

Máté Erdélyi,

Abiy Yenesew

Publication year - 2020

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/acs.jnatprod.0c00245

Subject(s) - plasmodium falciparum , prenylation , stereochemistry , chemistry , strain (injury) , pharmacognosy , two dimensional nuclear magnetic resonance spectroscopy , biological activity , biology , in vitro , organic chemistry , biochemistry , enzyme , malaria , anatomy , immunology

Five new compounds-rhodimer ( 1 ), rhodiflavan A ( 2 ), rhodiflavan B ( 3 ), rhodiflavan C ( 4 ), and rhodacarpin ( 5 )-along with 16 known secondary metabolites, were isolated from the CH 2 Cl 2 -CH 3 OH (1:1) extract of the roots of Tephrosia rhodesica . They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2 - 5 , 9 , 15 , and 21 showed activity (100% at 10 μg and IC 50 = 5-15 μM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum .

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