4D-Printed Dynamic Materials in Biomedical Applications: Chemistry, Challenges, and Their Future Perspectives in the Clinical Sector | Zendy

Wenxian Zhou | Zendy; Zhiguang Qiao | Zendy; Ehsan Nazarzadeh Zare‬ | Zendy; Jinfeng Huang | Zendy; Xuan-Qi Zheng | Zendy; Xiaolei Sun | Zendy; Minmin Shao | Zendy; Hui Wang | Zendy; Xiaoyan Wang | Zendy; Dong Chen | Zendy; Jing Zheng | Zendy; Fang Shan | Zendy; Yan Michael Li | Zendy; Xiaolei Zhang | Zendy; Lei Yang | Zendy; Pooyan Makvandi | Zendy; Aimin Wu | Zendy

Open Access

4D-Printed Dynamic Materials in Biomedical Applications: Chemistry, Challenges, and Their Future Perspectives in the Clinical Sector

Author(s) -

Wenxian Zhou,

Zhiguang Qiao,

Ehsan Nazarzadeh Zare‬,

Jinfeng Huang,

Xuan-Qi Zheng,

Xiaolei Sun,

Minmin Shao,

Hui Wang,

Xiaoyan Wang,

Dong Chen,

Jing Zheng,

Fang Shan,

Yan Michael Li,

Xiaolei Zhang,

Lei Yang,

Pooyan Makvandi,

Aimin Wu

Publication year - 2020

Publication title -

journal of medicinal chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.01

H-Index - 261

eISSN - 1520-4804

pISSN - 0022-2623

DOI - 10.1021/acs.jmedchem.9b02115

Subject(s) - nanotechnology , 3d printed , biochemical engineering , perspective (graphical) , field (mathematics) , computer science , chemistry , biomedical engineering , engineering , materials science , artificial intelligence , mathematics , pure mathematics

Most of the biomedical materials printed using 3D bioprinting are static and are unable to alter/transform with dynamic changes in the internal environment of the body. The emergence of four-dimensional (4D) printing addresses this problem. By preprogramming dynamic polymer materials and their nanocomposites, 4D printing is able to produce the desired shapes or transform functions under specific conditions or stimuli to better adapt to the surrounding environment. In this review, the current and potential applications of 4D-printed materials are introduced in different aspects of the biomedical field, e.g., tissue engineering, drug delivery, and sensors. In addition, the existing limitations and possible solutions are discussed. Finally, the current limitations of 4D-printed materials along with their future perspective are presented to provide a basis for future research.

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