Open AccessDesign, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage
Author(s) -
Zilan Song,
Bo Liu,
Xia Peng,
Wangting Gu,
Yiming Sun,
Xing Li,
Yuping Xu,
Meiyu Geng,
Jing Ai,
Ao Zhang
Publication year - 2021
Publication title -
journal of medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.01
H-Index - 261
eISSN - 1520-4804
pISSN - 0022-2623
DOI - 10.1021/acs.jmedchem.1c01422
Subject(s) - chemistry , small molecule , linkage (software) , stereochemistry , cd8 , pharmacology , blockade , potency , structure–activity relationship , lead compound , ic50 , combinatorial chemistry , immune system , biochemistry , in vitro , receptor , immunology , gene , medicine , biology