Open AccessRapid Determination of Enantiomeric Excess via NMR Spectroscopy: A Research-Informed Experiment
Author(s) -
John Fossey,
Eric V. Anslyn,
William D. G. Brittain,
Steven D. Bull,
Brette M. Chapin,
Cécile S. Le Duff,
Tony D. James,
Glenn Lees,
Stephanie Lim,
Jennifer A. C. Lloyd,
Charles V. Manville,
Daniel T. Payne,
Kimberley A. Roper
Publication year - 2016
Publication title -
journal of chemical education
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.499
H-Index - 84
eISSN - 1938-1328
pISSN - 0021-9584
DOI - 10.1021/acs.jchemed.6b00355
Subject(s) - supramolecular chemistry , protocol (science) , enantiomer , nuclear magnetic resonance spectroscopy , chemistry , enantiomeric excess , spectroscopy , computer science , combinatorial chemistry , nanotechnology , organic chemistry , materials science , physics , molecule , medicine , catalysis , alternative medicine , pathology , quantum mechanics , enantioselective synthesis
An undergraduate chemistry experiment that draws from primary research is described. The experiment exploits chiral supramolecular assemblies for the determination of enantiomeric excess by 1H NMR spectroscopy. This report describes the delivery of the experiment to a cohort of students, and as a result of feedback from those involved, an optimized protocol is presented. Particular care has been taken to facilitate ready adoption in other institutions by providing comprehensive teaching support materials as well as technical guidance for supporting the experiment
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