Multicomponent Reactions: “Kinderleicht”
Author(s) -
Constantinos G. Neochoritis,
Tryfon ZarganesTzitzikas,
Kallia Katsampoxaki-Hodgetts,
Alexander Dömlingꝉ
Publication year - 2020
Publication title -
journal of chemical education
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.499
H-Index - 84
eISSN - 1938-1328
pISSN - 0021-9584
DOI - 10.1021/acs.jchemed.0c00290
Subject(s) - tetrazole , chemistry , moiety , combinatorial chemistry , process (computing) , derivative (finance) , simple (philosophy) , component (thermodynamics) , computer science , mathematics education , organic chemistry , psychology , epistemology , philosophy , programming language , physics , financial economics , economics , thermodynamics
A demonstration experiment of the synthesis of a novel tetrazole derivative via a multicomponent reaction (Ugi tetrazole four component reaction, UT-4CR) bearing a luminol moiety and a subsequent exploitation of its chemiluminescent properties is described. A complex product is generated in just one simple step, so simple that children can do it: "kinderleicht", German for dead easy. Students are stimulated, inspired, and involved in a multilevel active learning process using the Steps to Inquiry framework as a metacognitive tool that raises student awareness regarding scientific process and prompts them to ask their own questions discussing the merits of a mechanism and evaluating its effectiveness before they start their own cycles of inquiry.
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