New Alkaloids from Green Vegetable Soybeans and Their Inhibitory Activities on the Proliferation of Concanavalin A-Activated Lymphocytes | Zendy

Taoyun Wang | Zendy; Jianping Zhao | Zendy; Xiaoran Li | Zendy; Qiongming Xu | Zendy; Yanli Liu | Zendy; Ikhlas A. Khan | Zendy; Shilin Yang | Zendy

Open Access

New Alkaloids from Green Vegetable Soybeans and Their Inhibitory Activities on the Proliferation of Concanavalin A-Activated Lymphocytes

Author(s) -

Taoyun Wang,

Jianping Zhao,

Xiaoran Li,

Qiongming Xu,

Yanli Liu,

Ikhlas A. Khan,

Shilin Yang

Publication year - 2016

Publication title -

journal of agricultural and food chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.203

H-Index - 297

eISSN - 1520-5118

pISSN - 0021-8561

DOI - 10.1021/acs.jafc.5b06107

Subject(s) - alkaloid , chemistry , indole test , phytochemical , concanavalin a , inhibitory postsynaptic potential , chemical structure , carboxylic acid , stereochemistry , indole alkaloid , biochemistry , organic chemistry , biology , in vitro , neuroscience

A comprehensive phytochemical study of the chemical constituents of green vegetable soybeans resulted in the isolation of two new alkaloids, soyalkaloid A, 1, and isoginsenine, 2, together with four known ones, ginsenine, 3, (1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid, 4, (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid, 5, and indole-3-carboxylic acid, 6. The structures of compounds 1-6 were elucidated on the basis of spectroscopic and chemical analyses. All of the alkaloids were isolated from soybeans for the first time, and compound 1 was a new indole-type alkaloid with a novel carbocyclic skeleton. Their inhibitory activities on the proliferation of concanalin A-activated lymphocytes were assessed by CCK8 assay.

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