Influence of the Linker Length on the Cytotoxicity of Homobinuclear Ruthenium(II) and Gold(I) Complexes | Zendy

Lucinda K. Batchelor | Zendy; Emilia Păunescu | Zendy; Mylène Soudani | Zendy; Rosario Scopelliti | Zendy; Paul J. Dyson | Zendy

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Influence of the Linker Length on the Cytotoxicity of Homobinuclear Ruthenium(II) and Gold(I) Complexes

Author(s) -

Lucinda K. Batchelor,

Emilia Păunescu,

Mylène Soudani,

Rosario Scopelliti,

Paul J. Dyson

Publication year - 2017

Publication title -

inorganic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.348

H-Index - 233

eISSN - 1520-510X

pISSN - 0020-1669

DOI - 10.1021/acs.inorgchem.7b01082

Subject(s) - ruthenium , chemistry , lipophilicity , cytotoxicity , linker , ethylene glycol , stereochemistry , combinatorial chemistry , organic chemistry , in vitro , biochemistry , computer science , operating system , catalysis

Dinuclear metal complexes have emerged as a promising class of anticancer compounds with the ability to cross-link biomolecular targets. Here, we describe two novel series of phosphine-linked dinuclear ruthenium(II) p-cymene and gold(I) complexes, in which the length of the connecting poly(ethylene glycol) chain has been systematically modified. The impact of the multinuclearity, lipophilicity, and linker length on the antiproliferative activity of the compounds on tumorigenic (A2780 and A2780cisR) and nontumorigenic (HEK-293) cell lines was assessed. The dinuclear ruthenium(II) complexes were considerably more cytotoxic than their mononuclear counterparts, and a correlation between the lipophilicity of the linker and the cytotoxicity was observed, whereas the cytotoxicity of the gold(I) series is independent of these factors.

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