Open AccessFluorescent salen-type Zn(II) Complexes As Probes for Detecting Hydrogen Sulfide and Its Anion: Bioimaging Applications
Author(s) -
Maria Strianese,
Daniela Guarnieri,
Marina Lamberti,
Alessandro Landi,
Andrea Peluso,
Claudio Pellecchia
Publication year - 2020
Publication title -
inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 233
eISSN - 1520-510X
pISSN - 0020-1669
DOI - 10.1021/acs.inorgchem.0c02499
Subject(s) - chemistry , fluorescence , zinc , selectivity , hydrogen sulfide , adduct , naked eye , reactivity (psychology) , photochemistry , combinatorial chemistry , sulfur , detection limit , biochemistry , organic chemistry , chromatography , catalysis , medicine , physics , alternative medicine , quantum mechanics , pathology
In this work, we investigate the mode of interaction of a family of fluorescent zinc complexes with HS - and H 2 S. Different experiments, performed by diverse spectroscopic techniques, provide evidence that HS - binds the zinc center of all the complexes under investigation. Treatment with neutral H 2 S exhibits a markedly different reactivity which indicates selectivity for HS - over H 2 S of the systems under investigation. Striking color changes, visible to the naked eye, occur when treating the systems with HS - or by an H 2 S flow. Accordingly, also the fluorescence is modulated by the presence of HS - , with the possible formation of multiple adducts. The results highlight the potential of the devised systems to be implemented as HS - /H 2 S colorimetric and fluorescent sensors. Bioimaging experiments indicate the potential of using this class of compounds as probes for the detection of H 2 S in living cells.
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