Analyzing Drug Release Kinetics from Water-Soluble Polymers

The ability to develop predictive mathematical models of therapeutic release from pharmaceutical formulations has enormous potential to enhance our understanding of such systems and improve the controlled release of the payload. The current work describes the development and testing of a one-dimensional model of drug transport from amorphous, swelling/dissolving polymers. Model parameters, such as the diffusivities of water and drug, initial loading of the drug, polymer dissolution rate, drug–polymer interactions, and tablet thickness, were varied, demonstrating the ability to tune the release to be controlled by either drug diffusion or polymer chain disentanglement. In addition, predictions of the concentration profiles of water and drug within the gel layer, the locations of the erosion and swelling boundaries, and gel layer thickness were obtained for diffusion- and disentanglement-controlled release. To highlight the generalizability of this model, multiple parameters were varied, and it was shown th...