Protease-Sensitive Nanomaterials for Cancer Therapeutics and Imaging | Zendy

Caleb F. Anderson | Zendy; Honggang Cui | Zendy

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Protease-Sensitive Nanomaterials for Cancer Therapeutics and Imaging

Author(s) -

Caleb F. Anderson,

Honggang Cui

Publication year - 2017

Publication title -

industrial and engineering chemistry research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.878

H-Index - 221

eISSN - 1520-5045

pISSN - 0888-5885

DOI - 10.1021/acs.iecr.7b00990

Subject(s) - nanomaterials , cancer , cancer imaging , nanotechnology , protease , chemistry , materials science , medicine , biochemistry , enzyme

Many diseases can be characterized by the abnormal activity exhibited by various biomolecules, the targeting of which can provide therapeutic and diagnostic utility. Recent trends in medicine and nanotechnology have prompted the development of protease-sensitive nanomaterials systems for therapeutic, diagnostic, and theranostic applications. These systems can act specifically in response to the target enzyme and its associated disease conditions, thus enabling personalized treatment and improved prognosis. In this Review, we discuss recent advancements in the development of protease-responsive materials for imaging and drug delivery and analyze several representative systems to illustrate their key design principles.

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