Demethylation of Methylmercury in Bird, Fish, and Earthworm | Zendy

Alain Manceau | Zendy; JeanPaul Bourdineaud | Zendy; Ricardo Bezerra de Oliveira | Zendy; Sandra Layse Ferreira Sarrazin | Zendy; David P. Krabbenhoft | Zendy; Collin A. EaglesSmith | Zendy; Joshua T. Ackerman | Zendy; A. Robin Stewart | Zendy; Christian Ward-Deitrich | Zendy; M. Estela del Castillo Busto | Zendy; Heidi GoenagaInfante | Zendy; Aude Wack | Zendy; Marius Retegan | Zendy; Blanka Detlefs | Zendy; Pieter Glatzel | Zendy; Paco Bustamante | Zendy; Kathryn L. Nagy | Zendy; Brett A. Poulin | Zendy

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Demethylation of Methylmercury in Bird, Fish, and Earthworm

Author(s) -

Alain Manceau,

JeanPaul Bourdineaud,

Ricardo Bezerra de Oliveira,

Sandra Layse Ferreira Sarrazin,

David P. Krabbenhoft,

Collin A. EaglesSmith,

Joshua T. Ackerman,

A. Robin Stewart,

Christian Ward-Deitrich,

M. Estela del Castillo Busto,

Heidi GoenagaInfante,

Aude Wack,

Marius Retegan,

Blanka Detlefs,

Pieter Glatzel,

Paco Bustamante,

Kathryn L. Nagy,

Brett A. Poulin

Publication year - 2021

Publication title -

environmental science and technology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.851

H-Index - 397

eISSN - 1520-5851

pISSN - 0013-936X

DOI - 10.1021/acs.est.0c04948

Subject(s) - methylmercury , mercury (programming language) , environmental chemistry , chemistry , demethylation , inductively coupled plasma mass spectrometry , selenium , mass spectrometry , biochemistry , bioaccumulation , chromatography , organic chemistry , gene expression , computer science , dna methylation , gene , programming language

Toxicity of methylmercury (MeHg) to wildlife and humans results from its binding to cysteine residues of proteins, forming MeHg-cysteinate (MeHgCys) complexes that hinder biological functions. MeHgCys complexes can be detoxified in vivo , yet how this occurs is unknown. We report that MeHgCys complexes are transformed into selenocysteinate [Hg(Sec) 4 ] complexes in multiple animals from two phyla (a waterbird, freshwater fish, and earthworms) sampled in different geographical areas and contaminated by different Hg sources. In addition, high energy-resolution X-ray absorption spectroscopy (HR-XANES) and chromatography-inductively coupled plasma mass spectrometry of the waterbird liver support the binding of Hg(Sec) 4 o selenoprotein P and biomineralization of Hg(Sec) 4 o chemically inert nanoparticulate mercury selenide (HgSe). The results provide a foundation for understanding mercury detoxification in higher organisms and suggest that the identified MeHgCys to Hg(Sec) 4 demethylation pathway is common in nature.

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