Electrochemical Anion Sensing: Supramolecular Approaches

Anions play a vital role in a broad range of environmental, technological, and physiological processes, making their detection/quantification valuable. Electroanalytical sensors offer much to the selective, sensitive, cheap, portable, and real-time analysis of anion presence where suitable combinations of selective (noncovalent) recognition and transduction can be integrated. Spurred on by significant developments in anion supramolecular chemistry, electrochemical anion sensing has received considerable attention in the past two decades. In this review, we provide a detailed overview of all electroanalytical techniques that have been used for this purpose, including voltammetric, impedimetric, capacititive, and potentiometric methods. We will confine our discussion to sensors that are based on synthetic anion receptors with a specific focus on reversible, noncovalent interactions, in particular, hydrogen- and halogen-bonding. Apart from their sensory properties, we will also discuss how electrochemical techniques can be used to study anion recognition processes (e.g., binding constant determination) and will furthermore provide a detailed outlook over future efforts and promising new avenues in this field.