Recent Advances in the Synthesis of Hydantoins: The State of the Art of a Valuable Scaffold | Zendy

Laure Konnert | Zendy; Frédéric Lamaty | Zendy; Jean Martínez | Zendy; Evelina Colacino | Zendy

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Recent Advances in the Synthesis of Hydantoins: The State of the Art of a Valuable Scaffold

Author(s) -

Laure Konnert,

Frédéric Lamaty,

Jean Martínez,

Evelina Colacino

Publication year - 2017

Publication title -

chemical reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 20.528

H-Index - 700

eISSN - 1520-6890

pISSN - 0009-2665

DOI - 10.1021/acs.chemrev.7b00067

Subject(s) - hydantoin , chemistry , scaffold , nanotechnology , state of art , biochemical engineering , combinatorial chemistry , organic chemistry , biomedical engineering , engineering , materials science

The review highlights the hydantoin syntheses presented from the point of view of the preparation methods. Novel synthetic routes to various hydantoin structures, the advances brought to the classical methods in the aim of producing more sustainable and environmentally friendly procedures for the preparation of these biomolecules, and a critical comparison of the different synthetic approaches developed in the last twelve years are also described. The review is composed of 95 schemes, 8 figures and 528 references for the last 12 years and includes the description of the hydantoin-based marketed drugs and clinical candidates.

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