Modern Stereoselective Synthesis of Chiral Sulfinyl Compounds | Zendy

Elżbieta Wojaczyńska | Zendy; Jacek Wojaczyński | Zendy

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Modern Stereoselective Synthesis of Chiral Sulfinyl Compounds

Author(s) -

Elżbieta Wojaczyńska,

Jacek Wojaczyński

Publication year - 2020

Publication title -

chemical reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 20.528

H-Index - 700

eISSN - 1520-6890

pISSN - 0009-2665

DOI - 10.1021/acs.chemrev.0c00002

Subject(s) - enantiopure drug , chemistry , pharmacophore , enantioselective synthesis , stereoselectivity , combinatorial chemistry , catalysis , organic chemistry , stereochemistry

Chiral sulfinyl compounds, sulfoxides, sulfoximines, sulfinamides, and other derivatives, play an important role in asymmetric synthesis as versatile auxiliaries, ligands, and catalysts. They are also recognized as pharmacophores found in already marketed and well-sold drugs (e.g., esomeprazole) and used in drug design. This review is devoted to the modern methods of preparation of sulfinyl derivatives in enantiopure or enantiomerically enriched form. Selected new approaches leading to racemic products for which the asymmetric variant can be developed in the future are mentioned as well.

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