Open AccessEngineering of Single Magnetic Particle Carrier for Living Brain Cell Imaging: A Tunable T1-/T2-/Dual-Modal Contrast Agent for Magnetic Resonance Imaging Application
Author(s) -
YungKang Peng,
Cathy N. P. Lui,
Yuwei Chen,
ShangWei Chou,
Elizabeth H. Raine,
PiTai Chou,
Ken Kin Lam Yung,
Shik Chi Edman Tsang
Publication year - 2017
Publication title -
chemistry of materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.741
H-Index - 375
eISSN - 1520-5002
pISSN - 0897-4756
DOI - 10.1021/acs.chemmater.7b00884
Subject(s) - magnetic resonance imaging , nuclear magnetic resonance , materials science , dual (grammatical number) , contrast (vision) , dual mode , physics , optics , engineering , medicine , art , literature , radiology , aerospace engineering
Despite a variety of T1-T2 dual-modal contrast agents (DMCAs) reported for magnetic resonance imaging (MRI), no tuning of local induced magnetic field strength of an DMCA, which is important to modulate the overall T1 and T2 responses for imaging delicate cells, tissues, and organs, is yet available. Here, we show that a spatial arrangement of T1 and T2 components within a "nano zone" in a single core-shell nanoparticle carrier (i.e., DMCA with core Fe3O4 and MnO clusters in a silica shell) to produce the necessary fine-tuning effect. It is demonstrated that this particle after the anti-CD133 antibody immobilization allows both T1 and T2 imaging at higher resolution for living ependynmal brain cells of rodents with no local damage under a strong MRI magnetic field. This study opens a route to rational engineering of DMCAs for accurate magnetic manipulations in a safe manner
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