Role of Additives during Deracemization Using Temperature Cycling | Zendy

Giuseppe Belletti | Zendy; Hugo Meekes | Zendy; Floris P. J. T. Rutjes | Zendy; Elias Vlieg | Zendy

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Role of Additives during Deracemization Using Temperature Cycling

Author(s) -

Giuseppe Belletti,

Hugo Meekes,

Floris P. J. T. Rutjes,

Elias Vlieg

Publication year - 2018

Publication title -

crystal growth and design

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.966

H-Index - 155

eISSN - 1528-7505

pISSN - 1528-7483

DOI - 10.1021/acs.cgd.8b00856

Subject(s) - chirality (physics) , cycling , enantiomer , temperature cycling , phase (matter) , chemistry , solid state , ostwald ripening , chemical engineering , materials science , organic chemistry , nanotechnology , thermodynamics , chiral symmetry , thermal , physics , archaeology , quantum mechanics , nambu–jona lasinio model , engineering , history , quark

Temperature cycling, alongside Viedma ripening, has been established as a reliable method for deracemizing racemic mixtures of chiral compounds that crystallize as a conglomerate. Here we report that the speed of temperature cycling can be increased by using chiral additives. We also demonstrate that the chirality of the additive determines the final enantiomeric state of the solid phase. Viedma ripening experiments using equivalent conditions, with and without chiral additives, are always found to be slower.

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